منابع مشابه
Epigenetics and environmental chemicals.
PURPOSE OF REVIEW Epigenetics investigates heritable changes in gene expression occurring without changes in DNA sequence. Several epigenetic mechanisms, including DNA methylation, histone modifications, and microRNA expression, can change genome function under exogenous influence. Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemic...
متن کاملEpigenetics and environmental exposures.
It is becoming increasingly apparent that genetic factors are inadequate to fully explain many processes that shape development and disease. For example, monozygotic twin pairs, despite sharing identical DNA sequences, are often discordant for many traits and diseases, indicating that the same genotype can give rise to distinct phenotypes. This points towards the involvement of additional facto...
متن کاملEnvironmental Epigenetics
With over 350 journals, Oxford University Press is one of the largest publishers of scientific journals. In considering their portfolio recently, they realized they had no specific journals in the rapidly growing area of epigenetics. When they approached me about helping to establish a journal in this area, I considered what other journals had been developed. Several fine journals have been dev...
متن کاملEpigenetics and nutritional environmental signals.
All terrestrial life is influenced by multi-directional flows of information about its environment, enabling malleable phenotypic change through signals, chemical processes, or various forms of energy that facilitate acclimatization. Billions of biological co-inhabitants of the earth, including all plants and animals, collectively make up a genetic/epigenetic ecosystem by which adaptation/survi...
متن کاملEnvironmental signals and transgenerational epigenetics.
The ability of an environmental factor or toxicant to promote a phenotype or disease state not only in the individual exposed, but also in subsequent progeny for multiple generations, is termed transgenerational inheritance. The majority of environmental agents do not promote genetic mutations or alterations in DNA sequence, but do have the capacity to alter the epigenome. Although most environ...
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ژورنال
عنوان ژورنال: Current Opinion in Pediatrics
سال: 2009
ISSN: 1040-8703
DOI: 10.1097/mop.0b013e32832925cc